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Megakaryocytes in the hematopoietic stem cell niche

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Mesenchymal stromal cells are key components of hematopoietic stem cell (HSC) niches in the bone marrow. Two studies now show that hematopoietic-derived megakaryocytes also contribute to the HSC niche, regulating HSC quiescence and function.

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Figure 1: The majority of HSCs are perivascular, localizing to either arteriolar or sinusoidal niches, which consist of a number of different nonhematopoietic stromal cell types.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Ryan B. Day and Daniel C. Link are at the Department of Medicine, Washington University, St. Louis, Missouri, USA.,

    Ryan B. Day & Daniel C. Link

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  1. Ryan B. Day
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  2. Daniel C. Link
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Correspondence to Daniel C. Link.

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The authors declare no competing financial interests.

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Day, R., Link, D. Megakaryocytes in the hematopoietic stem cell niche. Nat Med 20, 1233–1234 (2014). https://doi.org/10.1038/nm.3745

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