References
Dienstmann, R. et al. Mol. Oncol. 8, 859–873 (2014).
Kumar, P., Henikoff, S. & Ng, P.C. Nat. Protoc. 4, 1073–1081 (2009).
Adzhubei, I.A. et al. Nat. Methods 7, 248–249 (2010).
Donnelly, P. Nature 456, 728–731 (2008).
Sander, J.D. & Joung, J.K. Nat. Biotechnol. 32, 347–355 (2014).
Jinek, M. et al. Science 337, 816–821 (2012).
Xue, W. et al. Nature 10.1038/nature13589 (6 August 2014).
Smurnyy, Y. et al. Nat. Chem. Biol. 10, 623–625 (2014).
Wang, H. et al. Cell 153, 910–918 (2013).
Tsai, S.Q. et al. Nat. Biotechnol. 32, 569–576 (2014).
Heckl, D. et al. Nat. Biotechnol. 32, 941–946 (2014).
Tang, Q. et al. Nat. Methods 11, 821–824 (2014).
Fu, Y. et al. Nat. Biotechnol. 31, 822–826 (2013).
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J.K.J. is a consultant for Horizon Discovery. J.K.J. has financial interests in Editas Medicine and Transposagen Biopharmaceuticals. J.K.J.'s interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies.
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Tsai, S., Iafrate, A. & Joung, J. Genome Editing: A Tool For Research and Therapy: Towards a functional understanding of variants for molecular diagnostics using genome editing. Nat Med 20, 1103–1104 (2014). https://doi.org/10.1038/nm.3722
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DOI: https://doi.org/10.1038/nm.3722
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