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Astrocyte-derived lactosylceramide implicated in multiple sclerosis

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Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system. A new study has shown that the lipid lactosylceramide, produced by astrocytes, contributes to disease progression in a mouse model of MS.

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Figure 1: LacCer signaling in astrocytes promotes CNS inflammation in chronic-progressive EAE.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Abdolmohamad Rostami and Bogoljub Ciric are at the Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.,

    Abdolmohamad Rostami & Bogoljub Ciric

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  1. Abdolmohamad Rostami
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  2. Bogoljub Ciric
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Correspondence to Abdolmohamad Rostami.

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The authors declare no competing financial interests.

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Rostami, A., Ciric, B. Astrocyte-derived lactosylceramide implicated in multiple sclerosis. Nat Med 20, 1092–1093 (2014). https://doi.org/10.1038/nm.3719

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