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Neuregulin-1 alleviates Charcot-Marie-Tooth disease in rats

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Disrupted differentiation of Schwann cells contributes to axonal loss in a rat model of Charcot-Marie-Tooth 1A neuropathy. Early neuregulin-1 treatment promotes Schwann cell differentiation, preserves axons and restores nerve function in this model.

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Figure 1: NRG1 promotes normal Schwann cell differentiation and preserves axonal integrity in a rat model of CMT1A.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Rudolf Martini is at the Department of Neurology, Section of Developmental Neurobiology, University Hospital Würzburg, Würzburg, Germany.,

    Rudolf Martini

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  1. Rudolf Martini
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Correspondence to Rudolf Martini.

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Martini, R. Neuregulin-1 alleviates Charcot-Marie-Tooth disease in rats. Nat Med 20, 984–985 (2014). https://doi.org/10.1038/nm.3684

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