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Atypical transforming growth factor–β signaling in the hypothalamus is linked to diabetes

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Aging and a high-fat diet are predisposing factors for type 2 diabetes. A study in mice suggests that dietary fat and aging lead to atypical transforming growth factor-β1 signaling in the hypothalamus, which disturbs whole-body glucose regulation.

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Figure 1: Hypothalamic TGF-β1 directly modulates systemic glucose levels through an atypical signaling mechanism.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Eliana P. Araujo and Licio A. Velloso are at the Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.,

    Eliana P Araujo & Licio A Velloso

  2. Claudio T. de Souza is at the Laboratory of Exercise Biochemistry and Physiology, Universidade do Sul Catarinense (UNESC), Crisciuma, Brazil.,

    Claudio T de Souza

Authors
  1. Eliana P Araujo
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  2. Claudio T de Souza
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  3. Licio A Velloso
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Corresponding author

Correspondence to Licio A Velloso.

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The authors declare no competing financial interests.

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Araujo, E., de Souza, C. & Velloso, L. Atypical transforming growth factor–β signaling in the hypothalamus is linked to diabetes. Nat Med 20, 985–987 (2014). https://doi.org/10.1038/nm.3673

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