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A new activity for SAMHD1 in HIV restriction

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Restriction factors are host cell proteins that inhibit retroviral infection. A new study using mutants of human HIV-1 restriction factor SAMHD1 suggests that it inhibits infection through degradation of viral RNA rather than through its dNTPase activity as previously suggested.

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Figure 1: SAMHD1 is a host restriction factor that blocks reverse transcription of HIV in nondividing cells, including macrophages, dendritic cells and resting CD4+ T cells.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Zhiyuan Yang and Warner C. Greene are at the Gladstone Institute of Virology and Immunology and the University of California–San Francisco, San Francisco, California, USA.,

    Zhiyuan Yang & Warner C Greene

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  1. Zhiyuan Yang
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  2. Warner C Greene
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Correspondence to Warner C Greene.

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The authors declare no competing financial interests.

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Yang, Z., Greene, W. A new activity for SAMHD1 in HIV restriction. Nat Med 20, 808–809 (2014). https://doi.org/10.1038/nm.3657

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