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Lightening up a notch: Notch regulation of energy metabolism

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Inhibiting Notch signaling induces adipose browning, improves systemic glucose tolerance and insulin sensitivity, and suppresses weight gain in mice.

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Figure 1: Notch signaling inhibition promotes adipose browning and improved energy homeostasis.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Thomas Gridley is at the Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA.,

    Thomas Gridley

  2. Department of Cell and Tissue Biology, Shingo Kajimura is at the University of California–San Francisco Diabetes Center, University of California–San Francisco, San Francisco, California, USA.,

    Shingo Kajimura

Authors
  1. Thomas Gridley
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  2. Shingo Kajimura
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Corresponding authors

Correspondence to Thomas Gridley or Shingo Kajimura.

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The authors declare no competing financial interests.

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Gridley, T., Kajimura, S. Lightening up a notch: Notch regulation of energy metabolism. Nat Med 20, 811–812 (2014). https://doi.org/10.1038/nm.3650

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