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Absence of leptin triggers type 1 diabetes

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Leptin deficiency, which is associated with type 1 diabetes, is a critical factor in the pathophysiology of this disease, a new study in rats shows. The lack of this hormone triggers a cascade of neuroendocrine events that affect adipose tissue and the liver, resulting in hyperglycemia and ketoacidosis (pages 759–763).

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Figure 1: T1D is an autoimmune disease that destroys pancreatic beta cells, resulting in insulin deficiency, which leads to hypergylcemia and ketoacidosis.

Debbie Maizels/Nature Publishing Group

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Authors and Affiliations

  1. Bettina Mittendorfer and Samuel Klein are at the Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.,

    Bettina Mittendorfer & Samuel Klein

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  1. Bettina Mittendorfer
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  2. Samuel Klein
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Correspondence to Samuel Klein.

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Mittendorfer, B., Klein, S. Absence of leptin triggers type 1 diabetes. Nat Med 20, 705–706 (2014). https://doi.org/10.1038/nm.3629

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