Skip to main content

Advertisement

SpringerLink
Log in

Young blood rejuvenates old brains

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Age-related cognitive decline occurs in many mammals, including humans, resulting from a decline in hippocampal function, and it is associated with reduced synaptic plasticity in hippocampal circuits. In this issue of Nature Medicine, a new study shows that cognitive impairment observed in aged mice is largely reversible following exposure to the blood of young mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Young mouse blood is able to rejuvenate aged mouse brains.

References

  1. Holtzman, D.M., Morris, J.C. & Goate, A.M. Sci. Transl. Med. 3, 77sr1 (2011).

    PubMed  PubMed Central  Google Scholar 

  2. Morrison, J.H. & Baxter, M.G. Nat. Rev. Neurosci. 13, 240–250 (2012).

    Article  CAS  Google Scholar 

  3. Bertoni-Freddari, C. et al. Ann. NY Acad. Sci. 1010, 635–638 (2003).

    Article  Google Scholar 

  4. Villeda, S.A. et al. Nat. Med. 20, 659–663 (2014).

    Article  CAS  Google Scholar 

  5. Kida, S. et al. Nat. Neurosci. 5, 348–355 (2002).

    Article  CAS  Google Scholar 

  6. Small, S.A. et al. Ann. Neurol. 51, 290–295 (2002).

    Article  Google Scholar 

  7. Villeda, S.A. et al. Nature 477, 90–94 (2011).

    Article  CAS  Google Scholar 

  8. Ruckh, J.M. et al. Cell Stem Cell 10, 96–103 (2012).

    Article  CAS  Google Scholar 

  9. Salpeter, S.J. et al. Diabetes 62, 2843–2848 (2013).

    Article  CAS  Google Scholar 

  10. Loffredo, F.S. et al. Cell 153, 828–839 (2013).

    Article  CAS  Google Scholar 

  11. Sinha, M. et al. Science 344, 649–652 (2014).

    Article  CAS  Google Scholar 

  12. Katsimpardi, L. et al. Science 344, 630–634 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Steven M. Paul is at the Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, USA.,

    Steven M Paul

  2. Steven M. Paul and Kiran Reddy are at Third Rock Ventures, Boston, Massachusetts, USA.,

    Steven M Paul & Kiran Reddy

Authors
  1. Steven M Paul
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kiran Reddy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Steven M Paul.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Paul, S., Reddy, K. Young blood rejuvenates old brains. Nat Med 20, 582–583 (2014). https://doi.org/10.1038/nm.3597

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.3597

  • Springer Nature America, Inc.

Search

Navigation