Skip to main content

Advertisement

Log in

Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment

  • Between Bedside and Bench
  • Published:

From Nature Medicine

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Repurposing metformin.

Kim Caesar/Nature Publishing Group

References

  1. Owen, M.R., Doran, E. & Halestrap, A.P. Biochem. J. 348, 607–614 (2000).

    Article  CAS  Google Scholar 

  2. Shaw, R.J. et al. Science 310, 1642–1646 (2005).

    Article  CAS  Google Scholar 

  3. Foretz, M. et al. J. Clin. Invest. 120, 2355–2369 (2010).

    Article  CAS  Google Scholar 

  4. Franciosi, M. et al. PLoS ONE 8, e71583 (2013).

    Article  CAS  Google Scholar 

  5. Suissa, S. & Azoulay, L. Diabetes Care 35, 2665–2673 (2012).

    Article  CAS  Google Scholar 

  6. Pollak, M. Nat. Rev. Cancer 12, 159–169 (2012).

    Article  CAS  Google Scholar 

  7. Pollak, M. J. Clin. Invest. 123, 3693–3700 (2013).

    Article  CAS  Google Scholar 

  8. Wallace, D.C. Nat. Rev. Cancer 12, 685–698 (2012).

    Article  CAS  Google Scholar 

  9. Zakikhani, M., Dowling, R., Fantus, I.G., Sonenberg, N. & Pollak, M. Cancer Res. 66, 10269–10273 (2006).

    Article  CAS  Google Scholar 

  10. Larsson, O. et al. Proc. Natl. Acad. Sci. USA 109, 8977–8982 (2012).

    Article  CAS  Google Scholar 

  11. Algire, C. et al. Oncogene 30, 1174–1182 (2011).

    Article  CAS  Google Scholar 

  12. Shackelford, D.B. et al. Cancer Cell 23, 143–158 (2013).

    Article  CAS  Google Scholar 

  13. Birsoy, K. et al. Nature 508, 108–112 (2014).

    Article  CAS  Google Scholar 

  14. Pollak, M. Cancer Cell 23, 263–264 (2013).

    Article  CAS  Google Scholar 

  15. Gontier, E. et al. Eur. J. Nucl. Med. Mol. Imaging 35, 95–99 (2008).

    Article  CAS  Google Scholar 

  16. Madiraju, A.K. et al. Nature published online, doi:10.1038/nature13270 (21 May 2014).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael Pollak.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pollak, M. Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment. Nat Med 20, 591–593 (2014). https://doi.org/10.1038/nm.3596

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.3596

  • Springer Nature America, Inc.

This article is cited by

Navigation