Skip to main content
SpringerLink
Log in

Interleukin-35 takes the 'B' line

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Regulatory B cells exert an immunosuppressive role by secreting the cytokine interleukin-10 (IL-10). Two studies have now identified B cell–derived IL-35 as both an inducer and a mediator of regulatory B cell function. IL-35 switched off inflammation in mouse models of autoimmunity, whereas its absence in B cells in mice enhanced survival after Salmonella enterica serovar Typhimurium infection. IL-35 could therefore be targeted for treating human autoimmune and infectious disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The immunosuppressive cytokine IL-35 induces the expansion of Breg cells, which secrete IL-35 to protect from autoimmune disease.

References

  1. Mauri, C. & Bosma, A. Annu. Rev. Immunol. 30, 221–241 (2012).

    Article  CAS  Google Scholar 

  2. Neves, P. et al. Immunity 33, 777–790 (2010).

    Article  CAS  Google Scholar 

  3. Yanaba, K. et al. Immunity 28, 639–650 (2008).

    Article  CAS  Google Scholar 

  4. Evans, J.G. et al. J. Immunol. 178, 7868–7878 (2007).

    Article  CAS  Google Scholar 

  5. Ding, Q. et al. J. Clin. Invest. 121, 3645–3656 (2011).

    Article  CAS  Google Scholar 

  6. Blair, P.A. et al. Immunity 32, 129–140 (2010).

    Article  CAS  Google Scholar 

  7. Yoshizaki, A. et al. Nature 491, 264–268 (2012).

    Article  CAS  Google Scholar 

  8. Flores-Borja, F. et al. Sci. Transl. Med. 5, 173ra123 (2013).

    Article  Google Scholar 

  9. Wang, R.-X. et al. Nat. Med. 20, 633–641 (2014).

    Article  Google Scholar 

  10. Collison, L.W. et al. Nature 450, 566–569 (2007).

    Article  CAS  Google Scholar 

  11. Collison, L.W. et al. Nat. Immunol. 13, 290–299 (2012).

    Article  CAS  Google Scholar 

  12. Shen, P. et al. Nature 507, 366–370 (2014).

    Article  CAS  Google Scholar 

  13. Vasconcellos, R., Carter, N.A., Rosser, E.C. & Mauri, C. J. Immunol. 187, 3402–3412 (2011).

    Article  CAS  Google Scholar 

  14. Bermejo, D.A. et al. Nat. Immunol. 14, 514–522 (2013).

    Article  CAS  Google Scholar 

  15. Collison, L.W. et al. Nat. Immunol. 11, 1093–1101 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Medicine, Claudia Mauri and Kiran Nistala are at the Centre for Rheumatology, University College London, London, UK.,

    Claudia Mauri & Kiran Nistala

Authors
  1. Claudia Mauri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kiran Nistala
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Claudia Mauri or Kiran Nistala.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mauri, C., Nistala, K. Interleukin-35 takes the 'B' line. Nat Med 20, 580–581 (2014). https://doi.org/10.1038/nm.3594

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.3594

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation