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An alternative DNA damage pathway to apoptosis in hematological cancers

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Although hematological cancers are genomically unstable, the mechanisms by which they evade DNA damage–induced cell death are largely unknown. A current study has revealed that the Hippo signaling pathway transcriptional regulator YAP1 activates an ABL1/p73-mediated proapoptotic effect in response to DNA damage, suggesting that YAP1 has a tumor suppressor function and that the Hippo pathway is a potential therapeutic target in human cancers.

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Figure 1: YAP1 alternative pathway to apoptosis in hematological cancers.

References

  1. Halazonetis, T.D., Gorgoulis, V.G. & Bartek, J. Science 319, 1352–1355 (2008).

    Article  CAS  Google Scholar 

  2. Levy, D., Adamovich, Y., Reuven, N. & Shaul, Y. Cell Death Differ. 14, 743–751 (2007).

    Article  CAS  Google Scholar 

  3. Cottini, F. et al. Nat. Med. 20, 599–606 (2014).

    Article  CAS  Google Scholar 

  4. Zhou, D. et al. Cancer Cell 16, 425–438 (2009).

    Article  CAS  Google Scholar 

  5. Liu, A.M., Wong, K.F., Jiang, X., Qiao, Y. & Luk, J.M. Biochim. Biophys. Acta 1826, 357–364 (2012).

    CAS  PubMed  Google Scholar 

  6. Harvey, K.F., Zhang, X. & Thomas, D.M. Nat. Rev. Cancer 13, 246–257 (2013).

    Article  CAS  Google Scholar 

  7. Zhao, B. et al. Genes Dev. 22, 1962–1971 (2008).

    Article  CAS  Google Scholar 

  8. Yu, F.X. & Guan, K.L. Genes Dev. 27, 355–371 (2013).

    Article  CAS  Google Scholar 

  9. Zhao, B., Tumaneng, K. & Guan, K.L. Nat. Cell Biol. 13, 877–883 (2011).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. John M. Luk is at China R&D and Scientific Affairs, Janssen, Shanghai, China.,

    John M Luk

  2. Kun-Liang Guan is at the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, California, USA.,

    Kun-Liang Guan

Authors
  1. John M Luk
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  2. Kun-Liang Guan
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Correspondence to John M Luk or Kun-Liang Guan.

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The authors declare no competing financial interests.

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Luk, J., Guan, KL. An alternative DNA damage pathway to apoptosis in hematological cancers. Nat Med 20, 587–588 (2014). https://doi.org/10.1038/nm.3593

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