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A protean protease: MMP-12 fights viruses as a protease and a transcription factor

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A new antiviral capacity for matrix metalloproteinase 12 (MMP-12) adds to our expanding understanding of matrix metalloproteinase biology, from matrix remodeling to host defense, in this issue of Nature Medicine (pages 493–502). Marchant et al. show that following viral infection, macrophages secrete MMP-12, which regulates antiviral immunity both as a transcription factor for IκBα, leading to interferon-α (IFN-α) secretion, and later by degrading extracellular IFN-α, resolving inflammation.

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Figure 1: Antiviral function of MMP-12.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. Nadine G. Dandachi and Steven D. Shapiro are in the Division of Pulmonary, Department of Medicine, Allergy, and Critical Care, University of Pittsburgh Medical Center and University of Pittsburgh, Pittsburgh, Pennsylvania, USA.,

    Nadine G Dandachi & Steven D Shapiro

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  1. Nadine G Dandachi
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  2. Steven D Shapiro
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Correspondence to Steven D Shapiro.

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Dandachi, N., Shapiro, S. A protean protease: MMP-12 fights viruses as a protease and a transcription factor. Nat Med 20, 470–472 (2014). https://doi.org/10.1038/nm.3561

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