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A Fox of a different color: FoxA1 programs a new regulatory T cell subset

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Interferon-β (IFN-β) is widely used to treat multiple sclerosis (MS), but its mechanism of protection remains obscure. A new study shows that IFN-β induces FoxA1+ regulatory T cells, a new regulatory T cell population, which suppress conventional T cells via programmed cell death 1 ligand 1. This cell subset limits disease in a mouse model of MS and was found in patients with MS who responded to IFN-β therapy (pages 272–282).

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Figure 1: IFN-β can generate FoxA1+ Treg cells in the CNS, which inhibit autoreactive T cells.

Marina Corral Spence

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Authors and Affiliations

  1. Greg M. Delgoffe and Dario A.A. Vignali are at the Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.,

    Greg M Delgoffe & Dario A A Vignali

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  1. Greg M Delgoffe
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  2. Dario A A Vignali
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Correspondence to Dario A A Vignali.

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The authors declare no competing financial interests.

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Delgoffe, G., Vignali, D. A Fox of a different color: FoxA1 programs a new regulatory T cell subset. Nat Med 20, 236–237 (2014). https://doi.org/10.1038/nm.3493

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