Retinoic acid and arsenic trioxide cure individuals with acute promyelocytic leukemia (APL). In mouse models, these drugs eradicate tumor cells by activating the tumor suppressors p53 and PML to induce senescence of cancer cells (pages 167–174).
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References
de Thé, H., Le Bras, M. & Lallemand-Breitenbach, V.J. Cell Biol. 198, 11–21 (2012).
Lo-Coco, F. et al. N. Engl. J. Med. 369, 111–121 (2013).
de Thé, H., Chomienne, C., Lanotte, M., Degos, L. & Dejean, A. Nature 347, 558–561 (1990).
Pearson, M. et al. Nature 406, 207–210 (2000).
Ferbeyre, G. et al. Genes Dev. 14, 2015–2027 (2000).
Bischof, O. et al. EMBO J. 21, 3358–3369 (2002).
Coppé, J.P. et al. PLoS Biol. 6, 2853–2868 (2008).
Xue, W. et al. Nature 445, 656–660 (2007).
Ablain, J. et al. Nat. Med. 20, 167–174 (2014).
Vernier, M. et al. Genes Dev. 25, 41–50 (2011).
de Stanchina, E. et al. Mol. Cell 13, 523–535 (2004).
Levine, A.J. & Oren, M. Nat. Rev. Cancer 9, 749–758 (2009).
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Bourdeau, V., Ferbeyre, G. Engaging a senescent response to cure leukemia. Nat Med 20, 123–124 (2014). https://doi.org/10.1038/nm.3469
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DOI: https://doi.org/10.1038/nm.3469
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