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Good guys gone bad: exTreg cells promote autoimmune arthritis

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Under most circumstances, Foxp3+ regulatory T (Treg) cells are a stable T cell population essential for maintaining self-tolerance. A study now shows that the inflammatory environment in autoimmune arthritis induces conversion of a subset of Foxp3+ T cells into interleukin-17–producing cells that contribute to disease pathogenesis (pages 62–68).

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Figure 1: Inflammatory conditions during arthritis convert a subset of Foxp3+ T cells into pathogenic TH17 cells.

Marina Corral Spence

References

  1. Rubtsov, Y.P. et al. Science 329, 1667–1671 (2010).

    Article  CAS  Google Scholar 

  2. Fu, W. et al. Nat. Immunol. 13, 972–980 (2012).

    Article  CAS  Google Scholar 

  3. Zhou, X. et al. Nat. Immunol. 10, 1000–1007 (2009).

    Article  CAS  Google Scholar 

  4. Cvetanovich, G.L. & Hafler, D.A. Curr. Opin. Immunol. 22, 753–760 (2010).

    Article  CAS  Google Scholar 

  5. Komatsu, N. et al. Nat. Med. 20, 62–68 (2014).

    Article  CAS  Google Scholar 

  6. Bailey-Bucktrout, S.L. et al. Immunity 39, 949–962 (2013).

    Article  CAS  Google Scholar 

  7. Edwards, J.R. & Mundy, G.R. Rheumatology 7, 235–243 (2011).

    PubMed  CAS  Google Scholar 

  8. Miyao, T. et al. Immunity 36, 262–275 (2012).

    Article  CAS  Google Scholar 

  9. Ohkura, N. et al. Immunity 37, 785–799 (2012).

    Article  CAS  Google Scholar 

  10. Williams, L.M. & Rudensky, A.Y. Nat. Immunol. 8, 277–284 (2007).

    Article  CAS  Google Scholar 

  11. Koch, M.A. et al. Nat. Immunol. 10, 595–602 (2009).

    Article  CAS  Google Scholar 

  12. Chaudhry, A. et al. Science 326, 986–991 (2009).

    Article  CAS  Google Scholar 

  13. Bettelli, E. et al. Nature 441, 235–238 (2006).

    Article  CAS  Google Scholar 

  14. Korn, T. et al. Proc. Natl. Acad. Sci. USA 105, 18460–18465 (2008).

    Article  Google Scholar 

  15. Nie, H. et al. Nat. Med. 19, 322–328 (2013).

    Article  CAS  Google Scholar 

  16. Korn, T. et al. Nat. Med. 13, 423–431 (2007).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Nicole Joller and Vijay K. Kuchroo are at the Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.,

    Nicole Joller & Vijay K Kuchroo

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  1. Nicole Joller
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  2. Vijay K Kuchroo
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Correspondence to Vijay K Kuchroo.

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Joller, N., Kuchroo, V. Good guys gone bad: exTreg cells promote autoimmune arthritis. Nat Med 20, 15–17 (2014). https://doi.org/10.1038/nm.3439

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