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Therapeutically reeducating macrophages to treat GBM

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Glioblastoma multiforme (GBM) is the most common type of aggressive malignant brain cancer. The current lack of successful therapeutics means that this disease has a dismal prognosis. However, a new study in mice offers hope for patients with GBM by demonstrating the efficacy of a novel drug that targets GBM-associated macrophages (pages 1264–1272).

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Figure 1: Tumor-macrophage interactions in glioma.

Katie Vicari

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Authors and Affiliations

  1. Christopher Garris and Mikael J. Pittet are at the Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.,

    Christopher Garris & Mikael J Pittet

  2. Christopher Garris is also in the Graduate Program in Immunology, Harvard Medical School, Boston, Massachusetts, USA.,

    Christopher Garris

Authors
  1. Christopher Garris
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  2. Mikael J Pittet
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Correspondence to Mikael J Pittet.

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The authors declare no competing financial interests.

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Garris, C., Pittet, M. Therapeutically reeducating macrophages to treat GBM. Nat Med 19, 1207–1208 (2013). https://doi.org/10.1038/nm.3355

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