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It takes nerves to recover from chemotherapy

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Anticancer cytotoxic drugs also kill normal progenitors found in rapidly regenerating tissues, resulting in prolonged hematopoietic insufficiency. Chemotherapy-induced toxicity of the nerves that regulate bone marrow niches required for regeneration of hematopoietic stem cells (HSCs) is involved in this insufficiency, which suggests that co-administration of neuroprotective agents may protect HSCs from the toxic effects of drugs such as cisplatin and vincristine (pages 695–703).

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Figure 1: Detrimental effect of cisplatin and vincristine on innervation of HSC niches.

Katie Vicari

References

  1. Elmaagacli, A.H. et al. Bone Marrow Transplant. 40, 659–664 (2007).

    Article  CAS  Google Scholar 

  2. Levesque, J.P. & Winkler, I.G. Curr. Opin. Organ Transplant. 13, 53–58 (2008).

    Article  Google Scholar 

  3. Philip, T. et al. N. Engl. J. Med. 333, 1540–1545 (1995).

    Article  CAS  Google Scholar 

  4. Attal, M. et al. N. Engl. J. Med. 335, 91–97 (1996).

    Article  CAS  Google Scholar 

  5. To, L.B., Levesque, J.-P. & Herbert, K.E. Blood 118, 4530–4540 (2011).

    Article  CAS  Google Scholar 

  6. Lucas, D. et al. Nat. Med. 19, 695–703 (2013).

    Article  CAS  Google Scholar 

  7. Katayama, Y. et al. Cell 124, 407–421 (2006).

    Article  CAS  Google Scholar 

  8. Méndez-Ferrer, S., Lucas, D., Battista, M. & Frenette, P.S. Nature 452, 442–447 (2008).

    Article  Google Scholar 

  9. Méndez-Ferrer, S. et al. Nature 466, 829–834 (2010).

    Article  Google Scholar 

  10. Winkler, I.G. et al. Nat. Med. 18, 1651–1657 (2012).

    Article  CAS  Google Scholar 

  11. Levesque, J.-P., Winkler, I.G. & Rasko, J.E.J. Bioessays 35, 183–190 (2013).

    Article  CAS  Google Scholar 

  12. Tournilhac, O. et al. Blood 103, 363–365 (2004).

    Article  Google Scholar 

  13. Clark, R.E. & Brammer, C.G. Bone Marrow Transplant. 22, 859–863 (1998).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. ingrid.winkler@mmri.mater.org.au

Authors and Affiliations

  1. Jean-Pierre Levesque and Ingrid G. Winkler are at Mater Research and University of Queensland, Woolloongabba, Queensland, Australia.,

    Jean-Pierre Levesque & Ingrid G Winkler

Authors
  1. Jean-Pierre Levesque
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  2. Ingrid G Winkler
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Correspondence to Jean-Pierre Levesque or Ingrid G Winkler.

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The authors declare no competing financial interests.

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Levesque, JP., Winkler, I. It takes nerves to recover from chemotherapy. Nat Med 19, 669–671 (2013). https://doi.org/10.1038/nm.3231

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