Blockage of transforming growth factor-β (TGF-β) signaling in subchondral bone after acute injury in rodents prevents aberrant bone remodeling and cartilage degeneration, suggesting that TGF-β signaling in bone may initiate osteoarthritis in some cases (pages 704–712).
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Katie Vicari
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Bush, J., Beier, F. TGF-β and osteoarthritis—the good and the bad. Nat Med 19, 667–669 (2013). https://doi.org/10.1038/nm.3228
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DOI: https://doi.org/10.1038/nm.3228
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