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A gut-heart connection in cardiometabolic regulation

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A new study establishes a link between glucagon-like peptide-1 (GLP-1) release from the gut and the cardiac hormone atrial natriuretic peptide, which lowers blood pressure. As GLP-1 receptor agonists are used to control glycemia in patients with type 2 diabetes, this new gut-heart axis suggests a role of these agents in overall cardiovascular homeostasis (pages 567–575).

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Figure 1: Cardiometabolic actions of GLP-1 and GLP-1 agonists through activation of atrial ANP secretion.

Katie Vicari

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Authors and Affiliations

  1. Division of Cardiovascular Diseases, Alessia Buglioni and John C. Burnett Jr. are at the Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, Minnesota, USA.,

    Alessia Buglioni & John C Burnett Jr

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  1. Alessia Buglioni
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  2. John C Burnett Jr
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Correspondence to John C Burnett Jr.

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The authors declare no competing financial interests.

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Buglioni, A., Burnett, J. A gut-heart connection in cardiometabolic regulation. Nat Med 19, 534–536 (2013). https://doi.org/10.1038/nm.3196

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