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Metabolic reprogramming in polycystic kidney disease

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A recent study shows that, like cancer cells, cells lacking the Pdk1 gene reprogram their metabolism to use aerobic glycolysis—the 'Warburg effect'. Targeting this pathway using a glucose analog that cannot be metabolized resulted in slower disease progression in mouse models of polycystic kidney disease. This work thus suggests a new potential therapeutic approach for autosomal dominant polycystic kidney disease (pages 488–493).

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Figure 1: Pkd1-deficient cells use the Warburg effect to fuel their proliferation.

Katie Vicari

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Authors and Affiliations

  1. Carmen Priolo and Elizabeth P. Henske are in the Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.,

    Carmen Priolo & Elizabeth P Henske

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  1. Carmen Priolo
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  2. Elizabeth P Henske
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Correspondence to Elizabeth P Henske.

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Priolo, C., Henske, E. Metabolic reprogramming in polycystic kidney disease. Nat Med 19, 407–409 (2013). https://doi.org/10.1038/nm.3140

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