Metabolically driven, chronic, low-grade inflammation has a crucial role in the pathogenesis of obesity and type 2 diabetes, and multiple stress-signaling cascades link insulin resistance and the immune response. An approved immunomodulatory drug is now shown to inhibit the kinases IKKε and TBK1, suppress inflammation and improve metabolic homeostasis in mouse models of obesity (pages 313–321).
Change history
22 March 2013
In the version of this article initially published, TBK1 was incorrectly referred to in a number of instances as TKB1. The error has been corrected in the HTML and PDF versions of the article.
References
Gregor, M.F. & Hotamisligil, G.S. Annu. Rev. Immunol. 29, 415–445 (2011).
Olefsky, J.M. & Glass, C.K. Annu. Rev. Physiol. 72, 219–246 (2010).
Odegaard, J.I. & Chawla, A. Science 339, 172–177 (2013).
Johnson, A.R., Milner, J.J. & Makowski, L. Immunol. Rev. 249, 218–238 (2012).
Hirosumi, J. et al. Nature 420, 333–336 (2002).
Yuan, M. et al. Science 293, 1673–1677 (2001).
Arkan, M.C. et al. Nat. Med. 11, 191–198 (2005).
Nakamura, T. et al. Cell 140, 338–348 (2010).
Carvalho-Filho, M.A. et al. Endocrinology 153, 5261–5274 (2012).
Reilly, S.M. et al. Nat. Med. 19, 313–321 (2013).
Baker, R.G., Hayden, M.S. & Ghosh, S.N.F. Cell Metab. 13, 11–22 (2011).
Chiang, S.-H. et al. Cell 138, 961–975 (2009).
Scheja, L., Heese, B. & Seedorf, K. Biochem. Biophys. Res. Commun. 407, 288–294 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Calay, E., Hotamisligil, G. Turning off the inflammatory, but not the metabolic, flames. Nat Med 19, 265–267 (2013). https://doi.org/10.1038/nm.3114
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3114
- Springer Nature America, Inc.
This article is cited by
-
Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome
Acta Pharmacologica Sinica (2022)
-
An ethyl-acetate fraction of Holothuria scabra modulates inflammation in vitro through inhibiting the production of nitric oxide and pro-inflammatory cytokines via NF-κB and JNK pathways
Inflammopharmacology (2020)
-
Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C
International Journal of Obesity (2018)
-
Evolutionaire geneeskunde
Bijblijven (2018)
-
Inflammation: The Dynamic Force of Health and Disease
Clinical Pharmacology & Therapeutics (2014)