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Apoptosis therapy: driving cancers down the road to ruin

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BH3 mimetics are a class of anticancer agents that hold the promise to trigger the central apoptotic machinery to set cancer cells on the road to ruin. Now, a new agent that selectively targets BCL-2, ABT-199, has been developed, with exciting preclinical and clinical results (pages 202–208).

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Figure 1: The friends and foes of BCL-2.

Marina Corral

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Authors and Affiliations

  1. Douglas R. Green is in the Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.,

    Douglas R. Green

  2. Henning Walczak is at the Centre for Cell Death, Cancer and Inflammation, University College London Cancer Institute, London, UK.,

    Henning Walczak

Authors
  1. Douglas R. Green
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  2. Henning Walczak
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Correspondence to Douglas R. Green or Henning Walczak.

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The authors declare no competing financial interests.

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Green, D., Walczak, H. Apoptosis therapy: driving cancers down the road to ruin. Nat Med 19, 131–133 (2013). https://doi.org/10.1038/nm.3076

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