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Compacting the heart with Notch

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Left ventricular noncompaction (LVNC) cardiomyopathy is a clinically and genetically heterogeneous disease that can be associated with substantial cardiovascular morbidity and mortality. A new study shows that mice with myocardial deletion of Mib1, which encodes a ubiquitin ligase in the Notch signaling pathway, have LVNC phenotypes and identifies MIB1 mutations in humans with LVNC (pages 193–201).

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Figure 1: Development of the myocardial compact layer during stages of cardiac morphogenesis.

Marina Corral

References

  1. Chin, T.K., Perloff, J.K., Williams, R.G., Jue, K. & Mohrmann, R. Circulation 82, 507–513 (1990).

    Article  CAS  Google Scholar 

  2. Grant, R.T. Heart 13, 273–283 (1926).

    Google Scholar 

  3. Maron, B.J. et al. Circulation 113, 1807–1816 (2006).

    Article  Google Scholar 

  4. Captur, G. & Nihoyannopoulos, P. Int. J. Cardiol. 140, 145–153 (2010).

    Article  Google Scholar 

  5. Oechslin, E. & Jenni, R. Eur. Heart J. 32, 1446–1456 (2011).

    Article  Google Scholar 

  6. Bleyl, S.B. et al. Am. J. Hum. Genet. 61, 868–872 (1997).

    Article  CAS  Google Scholar 

  7. Luxan, G. Nat. Med. 19, 193–201 (2013).

    Article  CAS  Google Scholar 

  8. de la Pompa, J.L. & Epstein, J.A. Dev. Cell 22, 244–254 (2012).

    Article  CAS  Google Scholar 

  9. Garg, V. et al. Nature 437, 270–274 (2005).

    Article  CAS  Google Scholar 

  10. Kopan, R. & Ilagan, M.X. Cell 137, 216–233 (2009).

    Article  CAS  Google Scholar 

  11. Le Borgne, R. Curr. Opin. Cell Biol. 18, 213–222 (2006).

    Article  CAS  Google Scholar 

  12. Blinder, J.J. et al. Am. J. Med. Genet. A. 155A, 2215–2220 (2011).

    Article  Google Scholar 

  13. Garg, V. et al. Nature 424, 443–447 (2003).

    Article  CAS  Google Scholar 

  14. Misra, C. et al. PLoS Genet. 8, e1002690 (2012).

    Article  CAS  Google Scholar 

  15. Shou, W. et al. Nature 391, 489–492 (1998).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Chaitali Misra and Vidu Garg are at the Center for Cardiovascular and Pulmonary Research and The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA.,

    Chaitali Misra & Vidu Garg

  2. Vidu Garg is also in the Departments of Pediatrics and Molecular Genetics, The Ohio State University, Columbus, Ohio, USA.,

    Vidu Garg

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  1. Chaitali Misra
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  2. Vidu Garg
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Correspondence to Vidu Garg.

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The authors declare no competing financial interests.

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Misra, C., Garg, V. Compacting the heart with Notch. Nat Med 19, 133–134 (2013). https://doi.org/10.1038/nm.3071

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