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Protective immunity from a germinal center sanctuary

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A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that replicating LAVs stimulate a protective immune response from a safe haven in the germinal centers of lymph nodes (pages 1673–1681).

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Figure 1: The germinal center acts as a sanctuary for SIV- or LAV-infected cells.

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Authors and Affiliations

  1. Harriet L. Robinson is at Geovax, Smyrna, Georgia, USA.,

    Harriet L Robinson

  2. Rama Rao Amara is at the Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.,

    Rama Rao Amara

Authors
  1. Harriet L Robinson
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  2. Rama Rao Amara
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Correspondence to Harriet L Robinson or Rama Rao Amara.

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The authors declare no competing financial interests.

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Robinson, H., Amara, R. Protective immunity from a germinal center sanctuary. Nat Med 18, 1614–1616 (2012). https://doi.org/10.1038/nm.2986

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