Androgen withdrawal–based therapeutic strategies for spinal and bulbar muscular atrophy (SBMA) have shown limited benefit in clinical trials, and therapies for this disease still remain a considerable challenge. The finding that a class of migraine medications, the triptans, improve disease in a mouse model of SBMA suggests a new route for future investigations into SBMA therapies (pages 1531–1538).
References
La Spada, A.R., Wilson, E.M., Lubahn, D.B., Harding, A.E. & Fischbeck, K.H. Nature 352, 77–79 (1991).
Kennedy, W.R., Alter, M. & Sung, J.H. Neurology 18, 671–680 (1968).
Sobue, G. et al. Brain 112, 209–232 (1989).
Chevalier-Larsen, E.S. et al. J. Neurosci. 24, 4778–4786 (2004).
Katsuno, M. et al. Neuron 35, 843–854 (2002).
Takeyama, K. et al. Neuron 35, 855–864 (2002).
Fernández-Rhodes, L.E. et al. Lancet Neurol. 10, 140–147 (2011).
Katsuno, M. et al. Lancet Neurol. 9, 875–884 (2010).
Rhodes, L.E. et al. Brain 132, 3242–3251 (2009).
Montie, H.L. et al. Hum. Mol. Genet. 18, 1937–1950 (2009).
Nedelsky, N.B. et al. Neuron 67, 936–952 (2010).
Orr, C.R. et al. J. Biol. Chem. 285, 35567–35577 (2010).
Minamiyama, M. et al. Nat. Med. 18, 1531–1538 (2012).
Ho, T.W., Edvinsson, L. & Goadsby, P.J. Nat. Rev. Neurol. 6, 573–582 (2010).
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Merry, D. Attacking the flank: targeting new pathways in SBMA. Nat Med 18, 1461–1463 (2012). https://doi.org/10.1038/nm.2967
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DOI: https://doi.org/10.1038/nm.2967
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