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A complex microworld in the gut: Harnessing pathogen-commensal relations

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Figure 1: Potential therapeutic strategies to treat pathogenic E. coli infection that target pathogen virulence factors and the gut microbiota.

Katie Vicari

References

  1. Kaper, J.B., Nataro, J.P. & Mobley, H.L. Nat. Rev. Microbiol. 2, 123–140 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. McDaniel, T.K., Jarvis, K.G., Donnenberg, M.S. & Kaper, J.B. Proc. Natl. Acad. Sci. USA 92, 1664–1668 (1995).

    Article  CAS  PubMed  Google Scholar 

  3. Deng, W. et al. Proc. Natl. Acad. Sci. USA 101, 3597–3602 (2004).

    Article  CAS  PubMed  Google Scholar 

  4. Frank, C. et al. N. Engl. J. Med. 365, 1771–1780 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Nataro, J.P., Yikang, D., Yingkang, D. & Walker, K. J. Bacteriol. 176, 4691–4699 (1994).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Rasko, D.A. et al. N. Engl. J. Med. 365, 709–717 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Rohde, H. et al. N. Engl. J. Med. 365, 718–724 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Wong, C.S., Jelacic, S., Habeeb, R.L., Watkins, S.L. & Tarr, P.I. N. Engl. J. Med. 342, 1930–1936 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Walterspiel, J.N., Ashkenazi, S., Morrow, A.L. & Cleary, T.G. Infection 20, 25–29 (1992).

    Article  CAS  PubMed  Google Scholar 

  10. Hill, D.A. et al. Mucosal Immunol. 3, 148–158 (2010).

    Article  CAS  PubMed  Google Scholar 

  11. Kamada, N. et al. Science 336, 1325–1329 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Badger, V.O., Ledeboer, N.A., Graham, M.B. & Edmiston, C.E. Jr. JPEN J. Parenter. Enteral Nutr. published online, 10.1177/0148607112446703 (10 May 2012).

  13. Gough, E., Shaikh, H. & Manges, A.R. Clin. Infect. Dis. 53, 994–1002 (2011).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Nobuhiko Kamada and Gabriel Núñez are in the Department of Pathology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.,

    Nobuhiko Kamada & Gabriel Núñez

  2. Grace Chen is in the Division of Hematology/Oncology, Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.,

    Grace Chen

Authors
  1. Nobuhiko Kamada
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  2. Grace Chen
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  3. Gabriel Núñez
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Corresponding author

Correspondence to Gabriel Núñez.

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The authors declare no competing financial interests.

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Kamada, N., Chen, G. & Núñez, G. A complex microworld in the gut: Harnessing pathogen-commensal relations. Nat Med 18, 1190–1191 (2012). https://doi.org/10.1038/nm.2900

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