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Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

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Figure 1: Pretreatment with imatinib does not protect primordial follicle oocytes from DNA damage–induced death or rescue cisplatin-induced loss of fertility in CD1 mice.

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Acknowledgements

This work was supported by fellowships and grants from the National Health and Medical Research Council (NHMRC Australia; program grants 494802 and 257502, fellowships to J.K.F. (441101), K.J.H. (494836), C.L.S. (406675), A.S. (461299) and T.P.S. (575503)); the Leukemia and Lymphoma Society (Specialised Centre of Research grant 7015), the US National Cancer Institute (CA 80188 and CA 43540) and the Victorian Cancer Council Fellowship to C.L.S. (CRF10_20). We thank M. Olshansky for help with calculations. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institutes Infrastructure Support Scheme.

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Author notes

  1. Jeffrey B Kerr, Karla J Hutt, Andreas Strasser, Jock K Findlay and Clare L Scott: These authors contributed equally to this work.

Authors and Affiliations

  1. Monash University, Clayton, Victoria, Australia

    Jeffrey B Kerr

  2. Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia

    Karla J Hutt & Jock K Findlay

  3. The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

    Michele Cook, Terence P Speed, Andreas Strasser & Clare L Scott

  4. Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

    Terence P Speed, Andreas Strasser & Clare L Scott

Authors
  1. Jeffrey B Kerr
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  2. Karla J Hutt
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  3. Michele Cook
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  4. Terence P Speed
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  5. Andreas Strasser
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  6. Jock K Findlay
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  7. Clare L Scott
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Contributions

J.B.K. and K.J.H. performed and planned experiments, interpreted data and wrote the manuscript. M.C. helped with experiments and contributed data. T.P.S. performed statistical analysis and contributed to manuscript writing. A.S., J.K.F. and C.L.S. conceived of the study, planned experiments, interpreted data and wrote the manuscript.

Corresponding author

Correspondence to Clare L Scott.

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The authors declare no competing financial interests.

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Supplementary Text and Figures

Supplementary Methods, Supplementary Tables 1–6 and Supplementary Figures 1–6 (PDF 7621 kb)

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Kerr, J., Hutt, K., Cook, M. et al. Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib. Nat Med 18, 1170–1172 (2012). https://doi.org/10.1038/nm.2889

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