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Fetuin-A: the missing link in lipid-induced inflammation

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The liver secretory protein fetuin-A (FetA) is now shown to act as an adaptor protein between free fatty acids (FFAs) and Toll-like receptor 4 (TLR4), providing the missing link between FFAs and chronic low-grade inflammation that impairs insulin sensitivity (pages 1279–1285).

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Figure 1: FetA functions as an adaptor between FFAs and TLR4 signaling in lipid-induced inflammation.

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Authors and Affiliations

  1. Jan Heinrichsdorff and Jerrold M. Olefsky are in the Department of Medicine, Division of Endocrinology and Metabolism, University of California–San Diego, La Jolla, California, USA.,

    Jan Heinrichsdorff & Jerrold M Olefsky

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  1. Jan Heinrichsdorff
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  2. Jerrold M Olefsky
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Correspondence to Jerrold M Olefsky.

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The authors declare no competing financial interests.

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Heinrichsdorff, J., Olefsky, J. Fetuin-A: the missing link in lipid-induced inflammation. Nat Med 18, 1182–1183 (2012). https://doi.org/10.1038/nm.2869

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