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Germs gone wild

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The normally harmless behavior of bacteria in the intestinal tract is maintained by community structure and the integrity of host defenses. When either or both of these are compromised, a few disgruntled outcasts can cause a riot, taking down the whole neighborhood (pages 799–806).

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Figure 1: Epithelial integrity and microbial composition affect intestinal homeostasis and the innate immune response.

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Authors and Affiliations

  1. Namiko Hoshi and Ruslan Medzhitov are at the Howard Hughes Medical Institute and Yale University Medical School, New Haven, Connecticut, USA.,

    Namiko Hoshi & Ruslan Medzhitov

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  1. Namiko Hoshi
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  2. Ruslan Medzhitov
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Correspondence to Ruslan Medzhitov.

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The authors declare no competing financial interests.

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Hoshi, N., Medzhitov, R. Germs gone wild. Nat Med 18, 654–656 (2012). https://doi.org/10.1038/nm.2767

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