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Activation of BK channels may not be required for bitter tastant–induced bronchodilation

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Figure 1: Effect of chloroquine on BK channel currents in mouse airway smooth muscle cells.
Figure 2: Lack of an effect of BK channel blockers on bitter tastant–induced relaxation in mouse intrapulmonary mainstem bronchi.

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Acknowledgements

We thank J. Walsh for helpful discussions. This work was supported by US National Heart, Lung, and Blood Institute grant HL73875 (to R.Z.) and the National Basic Research Program of China (2009CB941602) (to M.-S.Z.).

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Author notes

  1. Min-Sheng Zhu and Ronghua ZhuGe: These authors contributed equally to this work.

Authors and Affiliations

  1. Model Animal Research Center, Nanjing University, Nanjing, China

    Cheng-Hai Zhang, Chen Chen & Min-Sheng Zhu

  2. School of Life Sciences, Wenzhou Medical College, Wenzhou, China

    Chen Chen & Min-Sheng Zhu

  3. Biomedical Imaging Group, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Lawrence M Lifshitz, Kevin E Fogarty & Ronghua ZhuGe

  4. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Lawrence M Lifshitz & Kevin E Fogarty

  5. Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Ronghua ZhuGe

Authors
  1. Cheng-Hai Zhang
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  2. Chen Chen
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  3. Lawrence M Lifshitz
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  4. Kevin E Fogarty
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  5. Min-Sheng Zhu
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Corresponding authors

Correspondence to Min-Sheng Zhu or Ronghua ZhuGe.

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Supplementary Methods and Supplementary Figure 1 (PDF 235 kb)

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Zhang, CH., Chen, C., Lifshitz, L. et al. Activation of BK channels may not be required for bitter tastant–induced bronchodilation. Nat Med 18, 648–650 (2012). https://doi.org/10.1038/nm.2733

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