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Host defense against malaria favors Salmonella

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The beneficial cytoprotective effects of heme oxygenase-1 (HO-1) in malaria infection are counterpoised by higher susceptibility to nontyphoidal Salmonella (NTS) bacteremia. A new study in mice co-infected with malaria and Salmonella provides a mechanism for the long-recognized association between malaria and NTS infection in African children.

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Figure 1: Opposing consequences of inhibiting oxidative burst function through induction of HO-1 during malaria and NTS co-infection.

Katie Vicari

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Authors and Affiliations

  1. Calman A. MacLennan is at the Novartis Vaccines Institute for Global Health, Siena, Italy.,

    Calman A MacLennan

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  1. Calman A MacLennan
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Correspondence to Calman A MacLennan.

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Competing interests

C.A.M. is an employee of the Novatis Vaccines Institute for Global Health and the recipient of a clinical research fellowship from GlaxoSmithKline.

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MacLennan, C. Host defense against malaria favors Salmonella. Nat Med 18, 21–22 (2012). https://doi.org/10.1038/nm.2636

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