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Telomerase at the center of collapsing glomerulopathy

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Collapsing glomerulopathy, the classic kidney lesion in HIV-associated nephropathy, is characterized by the closure of glomerular capillary loops and epithelial cell proliferation. A new study shows that upregulation of TERT, the reverse transcriptase component of telomerase, in podocytes, the key filtration cells in the kidney, plays a major part in the development of this condition by activating Wnt signaling (pages 111–119).

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Figure 1: Pathogenic mechanisms in collapsing glomerulopathy.

Katie Vicari

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Authors and Affiliations

  1. Sumant S. Chugh and Lionel C. Clement are at the Glomerular Disease Therapeutics Laboratory and Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.,

    Sumant S Chugh & Lionel C Clement

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  1. Sumant S Chugh
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  2. Lionel C Clement
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Correspondence to Sumant S Chugh.

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Competing interests

S.S.C. is founder and president of GDTHERAPYand has filed patents on the use of sialic acid precursors and mutant forms of angiopoietin-like-4 for the treatment of nephrotic syndrome.

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Chugh, S., Clement, L. Telomerase at the center of collapsing glomerulopathy. Nat Med 18, 26–27 (2012). https://doi.org/10.1038/nm.2602

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