Skip to main content
SpringerLink
Log in

Treg cells: patrolling a dangerous neighborhood

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

How B cell tolerance is retained during somatic hypermutation in germinal centers is incompletely understood. Two studies now show that Foxp3+ regulatory T cells undergo functional specialization to limit the magnitude of the germinal center response, and they may contribute to our understanding of how germinal center–mediated autoimmunity is prevented (pages 975–982 and 983–988).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: TFR cell–mediated regulation of the germinal center reaction.

References

  1. Guo, W. et al. J. Exp. Med. 207, 2225–2237 (2010).

    Article  CAS  Google Scholar 

  2. Ray, S.K., Putterman, C. & Diamond, B. Proc. Natl. Acad. Sci. USA 93, 2019–2024 (1996).

    Article  CAS  Google Scholar 

  3. Vinuesa, C.G., Sanz, I. & Cook, M.C. Nat. Rev. Immunol. 9, 845–857 (2009).

    Article  CAS  Google Scholar 

  4. Crotty, S. Annu. Rev. Immunol. 29, 621–663 (2011).

    Article  CAS  Google Scholar 

  5. Sakaguchi, S., Yamaguchi, T., Nomura, T. & Ono, M. Cell 133, 775–787 (2008).

    Article  CAS  Google Scholar 

  6. Godfrey, V.L., Wilkinson, J.E. & Russell, L.B. Am. J. Pathol. 138, 1379–1387 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Huter, E.N., Natarajan, K., Torgerson, T.R., Glass, D.D. & Shevach, E.M. J. Invest. Dermatol. 130, 1391–1399 (2010).

    Article  CAS  Google Scholar 

  8. Seo, S.J. et al. Immunity 16, 535–546 (2002).

    Article  CAS  Google Scholar 

  9. Lim, H.W., Hillsamer, P., Banham, A.H. & Kim, C.H. J. Immunol. 175, 4180–4183 (2005).

    Article  CAS  Google Scholar 

  10. Linterman, M.A. et al. Nat. Med. 17, 975–982 (2011).

    Article  CAS  Google Scholar 

  11. Chung, Y. et al. Nat. Med. 17, 983–988 (2011).

    Article  CAS  Google Scholar 

  12. Campbell, D.J. & Koch, M.A. Nat. Rev. Immunol. 11, 119–130 (2011).

    Article  CAS  Google Scholar 

  13. Schwartzberg, P.L., Mueller, K.L., Qi, H. & Cannons, J.L. Nat. Rev. Immunol. 9, 39–46 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Daniel J. Campbell and Meghan A. Koch are at the Benaroya Research Institute, Seattle, Washington, USA.,

    Daniel J Campbell & Meghan A Koch

  2. Daniel J. Campbell is also in the Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA.,

    Daniel J Campbell

Authors
  1. Daniel J Campbell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Meghan A Koch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniel J Campbell.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Campbell, D., Koch, M. Treg cells: patrolling a dangerous neighborhood. Nat Med 17, 929–930 (2011). https://doi.org/10.1038/nm.2433

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2433

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation