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Killing the messenger to maintain control of HIV

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Certain human leukocyte antigen (HLA) alleles are associated with vigorous human immunodeficiency virus (HIV)-specific CD8+ T cell responses and good clinical outcomes. A new study suggests that CD8+ T cell–mediated killing of regulatory CD4+ T cells may partially explain how people with these protective alleles control HIV-1 replication (pages 989–995).

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Figure 1: CD8+ T cells expressing protective HLA alleles mediate protection from HIV in infected LNTPs.

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Authors and Affiliations

  1. Joel N. Blankson is at the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.,

    Joel N Blankson

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  1. Joel N Blankson
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Correspondence to Joel N Blankson.

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Blankson, J. Killing the messenger to maintain control of HIV. Nat Med 17, 927–928 (2011). https://doi.org/10.1038/nm.2427

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