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Nervous about immunity: neuronal signals control innate immune system

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The molecular mechanisms by which the nervous system influences innate immunity to pathogens remain mysterious. Two new studies show that neuronal products modulate established innate immune signaling pathways operative in the Caenorhabditis elegans intestine.

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Figure 1: Model for neuronal regulation of the innate immune response of intestinal cells to bacterial infection.

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Authors and Affiliations

  1. Cheng-Yuan Kao, Ferdinand C.O. Los and Raffi V. Aroian are in the Section of Cell and Developmental Biology, University of California, San Diego La Jolla, California 92093, USA. raroian@ucsd.edu,

    Cheng-Yuan Kao, Ferdinand C O Los & Raffi V Aroian

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  1. Cheng-Yuan Kao
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  2. Ferdinand C O Los
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  3. Raffi V Aroian
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Kao, CY., Los, F. & Aroian, R. Nervous about immunity: neuronal signals control innate immune system. Nat Immunol 9, 1329–1330 (2008). https://doi.org/10.1038/ni1208-1329

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