The protein kinase NIK is regulated by a complex of ubiquitin ligases that destroys it. When NIK-activating receptors are triggered, the ubiquitin ligase complex self-destructs.
This is a preview of subscription content, log in via an institution to check access.
References
Zarnegar, B.J. et al. Nat. Immunol. 9, 1371–1378 (2008).
Vallabhapurapu, S. et al. Nat. Immunol. 9, 1364–1370 (2008).
Malinin, N.L., Boldin, M.P., Kovalenko, A.V. & Wallach, D. Nature 385, 540–544 (1997).
Liao, G., Zhang, M., Harhaj, E.W. & Sun, S.C. J. Biol. Chem. 279, 26243–26250 (2004).
Varfolomeev, E. & Vucic, D. Cell Cycle 7, 1511–1521 (2008).
Xiao, G. et al. Cytokine Growth Factor Rev. 17, 281–293 (2006).
Sasaki, Y. et al. Proc. Natl. Acad. Sci. USA 105, 10883–10888 (2008).
Ashwell, J.D. J. Cell Biol. 182, 15–17 (2008).
He, J.Q. et al. J. Biol. Chem. 282, 3688–3694 (2007).
Vaux, D.L. & Silke, J. Nat. Rev. Mol. Cell Biol. 6, 287–297 (2005).
Steller, H. Cell Death Differ. 15, 1132–1138 (2008).
Mordmuller, B. et al. EMBO Rep. 4, 82–87 (2003).
Xiao, G. & Sun, S.C. J. Biol. Chem. 275, 21081–21085 (2000).
Ramakrishnan, P., Wang, W. & Wallach, D. Immunity 21, 477–489 (2004).
Stark, G.R. Cytokine Growth Factor Rev. 18, 419–423 (2007).
Basak, S. et al. Cell 128, 369–381 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wallach, D., Kovalenko, A. Self-termination of the terminator. Nat Immunol 9, 1325–1327 (2008). https://doi.org/10.1038/ni1208-1325
Issue Date:
DOI: https://doi.org/10.1038/ni1208-1325
- Springer Nature America, Inc.