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Alternative lifestyles of T cells

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T cells are intrinsically more malleable than previously thought. Two studies now show that existing T helper type 2 cells can be converted into alternative CD4+ T helper cells that coexpress interleukins 9 and 10.

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Figure 1: Functional plasticity of T cells: the cytokine environment controls the lineage conversion of a T helper subset.

References

  1. O'Shea, J.J. et al. Nat. Immunol. 9, 450–453 (2008).

    Article  CAS  Google Scholar 

  2. Murphy, E. et al. J. Exp. Med. 183, 901–913 (1996).

    Article  CAS  Google Scholar 

  3. Veldhoen, M. et al. Nat. Immunol. 9, 1341–1346 (2008).

    Article  CAS  Google Scholar 

  4. Dardalhon, V. et al. Nat. Immunol. 9, 1347–1355 (2008).

    Article  CAS  Google Scholar 

  5. Wei, J. et al. Proc. Natl. Acad. Sci. USA 104, 18169–18174 (2007).

    Article  CAS  Google Scholar 

  6. Mantel, P.Y. et al. PLoS Biol. 5, e329 (2007).

    Article  Google Scholar 

  7. Zhou, L. et al. Nature 453, 236–240 (2008)..

    Article  CAS  Google Scholar 

  8. Izcue, A. et al. Immunity 28, 559–570 (2008).

    Article  CAS  Google Scholar 

  9. Mucida, D. et al. Science 317, 256–260 (2007).

    Article  CAS  Google Scholar 

  10. Cliffe, L.J. et al. Adv. Parasitol. 57, 255–307 (2004).

    Article  Google Scholar 

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Tato, C., Cua, D. Alternative lifestyles of T cells. Nat Immunol 9, 1323–1325 (2008). https://doi.org/10.1038/ni1208-1323

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