T cells are intrinsically more malleable than previously thought. Two studies now show that existing T helper type 2 cells can be converted into alternative CD4+ T helper cells that coexpress interleukins 9 and 10.
References
O'Shea, J.J. et al. Nat. Immunol. 9, 450–453 (2008).
Murphy, E. et al. J. Exp. Med. 183, 901–913 (1996).
Veldhoen, M. et al. Nat. Immunol. 9, 1341–1346 (2008).
Dardalhon, V. et al. Nat. Immunol. 9, 1347–1355 (2008).
Wei, J. et al. Proc. Natl. Acad. Sci. USA 104, 18169–18174 (2007).
Mantel, P.Y. et al. PLoS Biol. 5, e329 (2007).
Zhou, L. et al. Nature 453, 236–240 (2008)..
Izcue, A. et al. Immunity 28, 559–570 (2008).
Mucida, D. et al. Science 317, 256–260 (2007).
Cliffe, L.J. et al. Adv. Parasitol. 57, 255–307 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tato, C., Cua, D. Alternative lifestyles of T cells. Nat Immunol 9, 1323–1325 (2008). https://doi.org/10.1038/ni1208-1323
Issue Date:
DOI: https://doi.org/10.1038/ni1208-1323
- Springer Nature America, Inc.