Skip to main content

Advertisement

SpringerLink
Log in

Macrophage tolerance: CD47–SIRP-α–mediated signals matter

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Inhibition of phagocyte activity depends on the ligation of SIRP-α by CD47. New findings show that Sirpa polymorphisms influence the engraftment and tolerance of xenogeneic transplants in NOD-SCID mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The interactions of innate and adaptive immune cells of the recipient organism with transplanted donor cells.

Kim Caesar

References

  1. Takenaka, K. et al. Nat. Immunol. 8, 1313–1323 (2007).

    Article  CAS  PubMed  Google Scholar 

  2. van Beek, E.M., Cochrane, F., Barclay, A.N. & van den Berg, T.K. J. Immunol. 175, 7781–7787 (2005).

    Article  CAS  PubMed  Google Scholar 

  3. Barclay, A.N. & Brown, M.H. Nat. Rev. Immunol. 6, 457–464 (2006).

    Article  CAS  PubMed  Google Scholar 

  4. Brown, E.J. & Frazier, W.A. Trends Cell Biol. 11, 130–135 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. Oldenborg, P.A. et al. Science 288, 2051–2054 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Blazar, B.R. et al. J. Exp. Med. 194, 541–549 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lindberg, F.P. et al. Science 274, 795–798 (1996).

    Article  CAS  PubMed  Google Scholar 

  8. Ishikawa-Sekigami, T. et al. Biochem. Biophys. Res. Commun. 343, 1197–1200 (2006).

    Article  CAS  PubMed  Google Scholar 

  9. Wang, H. et al. Proc. Natl. Acad. Sci. USA 104, 13744–13749 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Gardai, S.J. et al. Cell 123, 321–334 (2005).

    Article  CAS  PubMed  Google Scholar 

  11. Oldenborg, P.A. Leuk. Lymphoma 45, 1319–1327 (2004).

    Article  CAS  PubMed  Google Scholar 

  12. Ide, K. et al. Proc. Natl. Acad. Sci. USA 104, 5062–5066 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Shultz, L.D., Ishikawa, F. & Greiner, D.L. Nat. Rev. Immunol. 7, 118–130 (2007).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hitoshi Takizawa is with the Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland.,

    Hitoshi Takizawa

  2. Markus G. Manz is with the Institute for Research in Biomedicine and the Department of Hematology, Oncology Institute of Southern Switzerland, Ospedale San Giovanni, CH-6500 Bellinzona, Switzerland. manz@irb.unisi.ch,

    Markus G Manz

Authors
  1. Hitoshi Takizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Markus G Manz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Takizawa, H., Manz, M. Macrophage tolerance: CD47–SIRP-α–mediated signals matter. Nat Immunol 8, 1287–1289 (2007). https://doi.org/10.1038/ni1207-1287

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni1207-1287

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation