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Pin1: a proline isomerase that makes you wheeze?

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The accumulation of eosinophils in lung tissue, an invariant feature of allergic asthma, requires autocrine production of the cytokine GM-CSF. New data suggest protein isomerization mediated by the enzyme Pin1 is key to the stability of GM-CSF mRNA and eosinophil survival.

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Figure 1: Pin1 stabilizes GM-CSF transcripts in response to eosinophil activation.

Katie Ris

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Anderson, P. Pin1: a proline isomerase that makes you wheeze?. Nat Immunol 6, 1211–1212 (2005). https://doi.org/10.1038/ni1205-1211

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