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Breaking down the barriers to cancer immunotherapy

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Abstract

Emerging insights into the mechanisms of activation and negative regulation of innate and adaptive immune cells are providing new opportunities for the development of safe and effective cancer vaccines.

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Figure 1: Innate and adaptive immune cell mediated tumoricidal activities.
Figure 2: Opportunities for adaptive immunotherapy and cancer vaccines.

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Author information

Authors and Affiliations

  1. Wistar Institute and The Ludwig Institute for Cancer, Philadelphia, 19104, Pennsylvania, USA

    Ellen Puré

  2. Memorial Sloan-Kettering Cancer Center, New York, 10021, New York, USA

    James P Allison

  3. Washington University School of Medicine, St. Louis, 63110, Missouri, USA

    Robert D Schreiber

Authors
  1. Ellen Puré
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  2. James P Allison
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  3. Robert D Schreiber
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Corresponding author

Correspondence to Ellen Puré.

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Puré, E., Allison, J. & Schreiber, R. Breaking down the barriers to cancer immunotherapy. Nat Immunol 6, 1207–1210 (2005). https://doi.org/10.1038/ni1205-1207

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  • DOI: https://doi.org/10.1038/ni1205-1207

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