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A novel axis of innate immunity in cancer

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Neutrophils can function as chief effector cells in inflammation but can also regulate excessive inflammatory responses by secreting anti-inflammatory cytokines. The acute-phase reactant SAA-1 seems to be pivotal in the control of such plasticity.

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Figure 1: NKT cell crosstalk counteracts SAA-1-induced differentiation of immunosuppressive neutrophils.

Marina Corral

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Authors and Affiliations

  1. Stephen R. Mattarollo and Mark J. Smyth are with the Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.,

    Stephen R Mattarollo & Mark J Smyth

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  1. Stephen R Mattarollo
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  2. Mark J Smyth
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Correspondence to Mark J Smyth.

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Mattarollo, S., Smyth, M. A novel axis of innate immunity in cancer. Nat Immunol 11, 981–982 (2010). https://doi.org/10.1038/ni1110-981

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