Human immunodeficiency virus type 1 (HIV-1) seems to avoid detection by nucleic acid sensors. This is probably due to the host exonuclease TREX1, which degrades HIV DNA generated during HIV-1 infection.
This is a preview of subscription content, log in via an institution to check access.
References
Yan, N. et al. Nat. Immunol. 11, 1005–1013 (2010).
Crow, Y.J. et al. Nat. Genet. 38, 917–920 (2006).
Lee-Kirsch, M.A. et al. Nat. Genet. 39, 1065–1067 (2007).
Stetson, D.B., Ko, J.S., Heidmann, T. & Medzhitov, R. Cell 134, 587–598 (2008).
Stetson, D.B. & Medzhitov, R. Immunity 24, 93–103 (2006).
Beignon, A.S. et al. J. Clin. Invest. 115, 3265–3275 (2005).
Gringhuis, S.I. et al. Nat. Immunol. 11, 419–426 (2010).
Ishikawa, H., Ma, Z. & Barber, G.N. Nature 461, 788–792 (2009).
Stetson, D.B. & Medzhitov, R. Immunity 25, 373–381 (2006).
Hornung, V. & Latz, E. Nat. Rev. Immunol. 10, 123–130 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Geijtenbeek, T. Host DNase TREX1 hides HIV from DNA sensors. Nat Immunol 11, 979–980 (2010). https://doi.org/10.1038/ni1110-979
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni1110-979
- Springer Nature America, Inc.
This article is cited by
-
Association of TREX1 polymorphism with disease progression in human immunodeficiency virus type-1 (HIV-1) infected patients
Virus Genes (2023)
-
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
Nature Communications (2018)
-
Human Disease Phenotypes Associated With Mutations in TREX1
Journal of Clinical Immunology (2015)