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NDP52: the missing link between ubiquitinated bacteria and autophagy

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Mammalian cells ubiquitinate bacteria that erroneously enter the cytosol and target these intruding microbes for destruction by autophagy. New work shows that the protein NDP52 directly binds to ubiquitinated bacteria and facilitates the assembly of an autophagic membrane that surrounds these invaders.

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Figure 1: Host response to cytosolic bacteria.

Kim Caesar

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Authors and Affiliations

  1. Stanimir Ivanov and Craig R. Roy are in the Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center of Molecular Medicine, New Haven, Connecticut, USA.,

    Stanimir Ivanov & Craig R Roy

Authors
  1. Stanimir Ivanov
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  2. Craig R Roy
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Correspondence to Craig R Roy.

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Ivanov, S., Roy, C. NDP52: the missing link between ubiquitinated bacteria and autophagy. Nat Immunol 10, 1137–1139 (2009). https://doi.org/10.1038/ni1109-1137

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