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Activated pDCs: open to new antigen-presentation possibilities

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Major histocompatibility complex class II molecules present peptides to CD4+ T cells. New findings indicate that conventional and plasmacytoid dendritic cells handle these molecules differently after activation.

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Figure 1: Dynamics of MHC class II antigen presentation.

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van den Hoorn, T., Neefjes, J. Activated pDCs: open to new antigen-presentation possibilities. Nat Immunol 9, 1208–1210 (2008). https://doi.org/10.1038/ni1108-1208

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