The regulation of gene expression through changes in chromatin structure is increasingly recognized as a chief component of activation of cells of the immune response. It now seems that histone demethylation of the promoter of the gene encoding the transcription factor IRF4 contributes to alternative macrophage activation.
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Bowdridge, S., Gause, W. Regulation of alternative macrophage activation by chromatin remodeling. Nat Immunol 11, 879–881 (2010). https://doi.org/10.1038/ni1010-879
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DOI: https://doi.org/10.1038/ni1010-879
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