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The importance of being earnestly selfish

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Agonist encounter can divert thymocytes into several unconventional T cell subsets, many of which exhibit regulatory properties. Unexpected findings indicate that agonist selection can drive the differentiation of interleukin 17–producing cells in the thymus.

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Figure 1: The classical and alternative selection pathways in the thymus.

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Authors and Affiliations

  1. Hilde Cheroutre, Daniel Mucida and Florence Lambolez are with the La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.,

    Hilde Cheroutre, Daniel Mucida & Florence Lambolez

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  1. Hilde Cheroutre
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  2. Daniel Mucida
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  3. Florence Lambolez
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Correspondence to Hilde Cheroutre.

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Cheroutre, H., Mucida, D. & Lambolez, F. The importance of being earnestly selfish. Nat Immunol 10, 1047–1049 (2009). https://doi.org/10.1038/ni1009-1047

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