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Putting ThPOK in place

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ThPOK is necessary for the differentiation of CD4+ helper T cells. Three new studies indicate that, unexpectedly, ThPOK is required only after initial specification to the CD4+ lineage.

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Figure 1: ThPOK acts 'downstream' of the TCR and GATA-3 to 'lock in' the CD4+ T cell fate.

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Authors and Affiliations

  1. J. Jeremiah Bell and Avinash Bhandoola are in the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. bhandooa@mail.med.upenn.edu,

    J Jeremiah Bell & Avinash Bhandoola

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  1. J Jeremiah Bell
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  2. Avinash Bhandoola
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Bell, J., Bhandoola, A. Putting ThPOK in place. Nat Immunol 9, 1095–1096 (2008). https://doi.org/10.1038/ni1008-1095

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