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T cell receptors get back to basics

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For both mice and humans, an invariant T cell receptor mediates the recognition of glycolipid antigens presented in the context of CD1d molecules. Crystal structure and mutagenesis-based analyses now identify a minimalist binding mode well suited to an 'innate-style' pattern-recognition function.

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Figure 1: Key characteristics for antigen recognition in TCR-glycolipid and TCR-peptide interactions.

Kim Caesar

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Authors and Affiliations

  1. E. Yvonne Jones is with the Cancer Research UK Receptor Structure Research Group, The Henry Wellcome Building for Genomic Medicine, Oxford OX3 7BN, UK. yvonne@strubi.ox.ac.uk,

    E Yvonne Jones

  2. Nuffield Department of Medicine, Mariolina Salio and Vincenzo Cerundolo are with the Cancer Research UK Tumor Immunology Group, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. vincenzo.cerundolo@imm.ox.ac.uk,

    Mariolina Salio & Vincenzo Cerundolo

Authors
  1. E Yvonne Jones
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  2. Mariolina Salio
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  3. Vincenzo Cerundolo
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The authors declare no competing financial interests.

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Jones, E., Salio, M. & Cerundolo, V. T cell receptors get back to basics. Nat Immunol 8, 1033–1035 (2007). https://doi.org/10.1038/ni1007-1033

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