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Fine-tuning NK cell responses: it's a family affair

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The adaptor SAP mediates activation signals in natural killer cells. However, its family members EAT-2 and ERT are negative regulators that help to fine-tune natural killer cell recognition of viruses and tumors.

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Figure 1: A balance of activating and inhibitory SH2D1 adaptors regulates signaling of the NK cell receptor 2B4 and possibly other related receptors.

Katie Ris

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Authors and Affiliations

  1. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

    Marco Colonna

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  1. Marco Colonna
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Colonna, M. Fine-tuning NK cell responses: it's a family affair. Nat Immunol 6, 961–962 (2005). https://doi.org/10.1038/ni1005-961

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